Label-free highly sensitive probe detection with novel hierarchical SERS substrates fabricated by nanoindentation and chemical reaction methods

• Jingran Zhang,
• Tianqi Jia,
• Yongda Yan,
• Li Wang,
• Peng Miao,
• Yimin Han,
• Xinming Zhang,
• Guangfeng Shi,
• Yanquan Geng,
• Zhankun Weng,
• Daniel Laipple and
• Zuobin Wang

Beilstein J. Nanotechnol. 2019, 10, 2483–2496, doi:10.3762/bjnano.10.239

• . The feasibility of the hierarchical SERS substrate is verified using R6G molecules. Finally, the enhancement factor using malachite green molecules was found to reach 5.089 × 109, which demonstrates that the production method is a simple, reproducible and low-cost method for machining a highly

• sensitive, hierarchical SERS substrate. Keywords: Ag nanoparticles; hierarchical substrates; malachite green molecules; nanoindentation; nanostructures; R6G; SERS; Introduction Surface-enhanced Raman scattering (SERS) has triggered significant research interest due to its suitability as an analytical tool

• R6G molecules are used as adsorption markers. Finally, the Raman intensities of malachite green molecules with low concentration are detected on the optimized hierarchical SERS substrates. This work combines force modulation indentation with chemical reaction methods. The hierarchical substrates